HPV vaccination is a vital tool in preventing cancers that affect all genders — yet uptake among boys in the UK remains below target. Our latest commentary explores why. Historical framing of HPV as a “girls’ vaccine,” low awareness of boys’ eligibility, and barriers in school-based delivery have all contributed to unequal coverage. Misconceptions, limited teacher training, and the underuse of healthcare professionals such as GPs, dentists, and pharmacists further widen the gap. We propose gender-inclusive messaging, streamlined consent processes, and digital tools to better support parents and improve uptake. Our ongoing research into parental attitudes toward vaccinating boys aged 9–12 will help shape future interventions and policy to achieve true gender equity in HPV protection. This commentary was authored by Dr Daniel Gaffiero, Stephanie Davey, Amelia Dytham, Rebecca Cotton, Rahim Hussein and Dr Michaela Christodoulaki.